NIASPAN is a prescription medication used along with diet and exercise when diet and exercise alone have been unsuccessful. What NIASPAN means for you:

  • With proper diet and exercise, NIASPAN works to help lower LDL ("bad") cholesterol and help raise HDL ("good") cholesterol in people with abnormal cholesterol levels and lower triglycerides ("fats") in your blood.
  • NIASPAN reduces the risk of another heart attack.
    NIASPAN has been shown to reduce the chance of having another heart attack in patients who have a prior history of heart attack and have high cholesterol.
  • NIASPAN can help slow down or lessen plaque buildup.
    Plaque buildup (fatty deposits) is a complex process and has a number of risk factors that lead up to it, including a family history of early heart disease, high blood pressure, smoking, diabetes, and abnormal cholesterol levels. Cholesterol and other substances can build up in the walls of the heart's arteries, resulting in plaque. NIASPAN can slow or even help clear away some plaque that builds on artery walls of the heart—when used in combination with diet and a bile acid-binding resin (another cholesterol medication) in patients who have a history of coronary artery disease and high cholesterol levels.

NIASPAN, combined with a bile acid-binding resin, has not been shown to prevent heart disease, heart attacks, or stroke.

Safety Considerations

  • NIASPAN should not be taken by people with stomach ulcers or liver or serious bleeding problems.
  • Severe liver damage has occurred when switching to a long-acting niacin, such as NIASPAN, from immediate-release niacin.
  • Blood tests are needed before and during treatment with NIASPAN to check for liver problems.
  • Contact a healthcare provider if serious side effects such as unexplained muscle pain, tenderness, or weakness develop. The risk of these side effects may be higher among elderly patients and patients with diabetes, kidney, or thyroid problems.
  • Tell your healthcare provider if you have a history of gout, drink large amounts of alcohol, or if you are diabetic and experience increases in blood sugar.
  • The most common side effect of NIASPAN is flushing (warmth, redness, itching, and/or tingling of the skin).

Deciding if NIASPAN is right for you

Only your doctor can decide if NIASPAN should be part of your treatment plan.

Niaspan and other medicines (including vitamins and herbal supplements) can affect how each works, or when taken together they may cause side effects.
Tell your healthcare provider about all the prescription and non-prescription medicines you take, including:
  • Aspirin
  • Cholesterol or triglyceride medication
  • Blood pressure medication
  • Anticoagulants, also known as blood thinners
  • Any products containing niacin or nicotinamide

Also tell your doctor if you consume large amounts of alcohol.

If eligible, save up to $70 for NIASPAN per 30-day supply*

If you have questions, please call 1-844-415-0681

* Eligible patients will pay the first $5 and receive up to a maximum savings of $70 for NIASPAN per 30-day supply. Eligibility: In Massachusetts, co-pay assistance is not available for products with certain generic equivalents (for example, any product with an AB-rated generic equivalent). Available to patients with commercial prescription insurance coverage for NIASPAN. Co-pay assistance program is not available to patients receiving prescription reimbursement under any federal, state or government-funded insurance programs (for example, Medicare (including Part D), Medicare Advantage, Medigap, Medicaid, TRICARE, Department of Defense or Veterans Affairs programs) or where prohibited by law. If at any time a patient begins receiving prescription drug coverage under any such federal, state or government-funded healthcare program, patient will no longer be able to use the NIASPAN, savings card and patient must call NIASPAN customer service to stop participation. Patients may not seek reimbursement for value received from the NIASPAN savings card from any third-party payers. Offer subject to change or discontinuance without notice. Restrictions, including monthly maximums, may apply. This is not health insurance.

Please see the full Prescribing Information for NIASPAN and discuss it with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org for assistance.

Legal Notices/Privacy Policy. Copyright 2013, AbbVie Inc., North Chicago, Illinois, U.S.A. If you have any questions about AbbVie's Niaspan.com website that have not been answered click here. This website and the information contained herein is intended for use by US residents only, is provided for informational purposes only and is not intended to replace a discussion with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider and consider the unique characteristics of each patient.


  • NIASPAN is not for people with liver problems, stomach ulcers, serious bleeding problems, or those allergic to any product ingredient.
  • Severe liver damage has occurred when switching to a long-acting niacin (NIASPAN) from immediate-release niacin. Do not switch between forms of niacin without talking to your healthcare provider.
  • Tell your healthcare provider about any unexplained muscle pain, tenderness, or weakness, as this could be a sign of a serious side effect. This risk increases when NIASPAN is taken, particularly in the elderly, diabetics, and those with kidney or thyroid problems.
  • NIASPAN should be used with caution if you consume large amounts of alcohol and/or have a past history of liver disease.
  • Your healthcare provider should do blood tests before and during treatment to check liver enzyme levels, as these can increase with treatment.
  • NIASPAN can cause an increase in blood sugar levels. If you have diabetes, check your blood sugar levels more frequently during the first few months or with NIASPAN dose changes.
  • Tell your healthcare provider if you have kidney problems or a history of gout. NIASPAN can cause an increase in uric acid levels.
  • The most common side effects with NIASPAN are flushing, diarrhea, nausea, vomiting, increased cough, and itching.
  • Flushing (warmth, redness, itching, and/or tingling of the skin) is a common side effect of NIASPAN therapy. It may vary in severity and is more likely to happen when starting NIASPAN or during dose increases. Flushing may get better after several weeks of consistent NIASPAN use. Talk to your doctor about how the symptoms of flushing are different from symptoms of a heart attack. By dosing at bedtime, flushing will likely occur during sleep. If awakened by flushing, get up slowly, especially if feeling dizzy or faint, or taking blood pressure medications.
  • If you are taking another cholesterol medication called a bile acid-binding resin (e.g., colestipol, cholestyramine) along with NIASPAN, take these medicines at least 4 to 6 hours apart.
  • Some medicines should not be taken with NIASPAN. Tell your healthcare provider about all the medicines you take, including aspirin, any cholesterol medication, blood pressure medication, blood thinner medication, or any products containing niacin or nicotinamide.

For more information, talk with your healthcare provider.


NIASPAN® (niacin extended-release) tablets are a prescription medication used along with diet when a low-cholesterol diet and exercise alone are not enough.

  • NIASPAN raises HDL ("good") cholesterol and lowers LDL ("bad") cholesterol and triglycerides in people with abnormal cholesterol levels.
  • NIASPAN is also used to lower the risk of heart attack in people who have had a heart attack and have high cholesterol.
  • In people with coronary artery disease and high cholesterol levels, NIASPAN, when used with a bile acid-binding resin (another cholesterol medicine), can slow down or lessen the buildup of plaque (fatty deposits) in your arteries.

Taking NIASPAN with another cholesterol-lowering medicine (simvastatin) does not reduce heart attacks or strokes more than taking simvastatin alone.